After a quarter century, the end is reportedly nigh for this trendy downtown eatery. 

The illustrious chef Jean-Georges Vongerichten’s Manhattan restaurant Mercer Kitchen will mark its last service before the end of this year.

Eater first reported news of the impending closure. 

A hot spot for celebrities and tourists alike, Mercer Kitchen has called its 99 Prince St. location within the Mercer Hotel home since 1998. Now, after more than two decades serving up salmon entrees and spinach pizza from the Christian Liaigre-designed basement location, it’s throwing in the towel. 

“It’s been 25 years,” said Vongerichten, Eater reported. “A great run.”

“Mercer Kitchen was one of the first restaurants in New York City to have a communal table, which remains popular to this day,” the eatery’s website claims, adding “There is an open kitchen, where guests can sit back and watch the show.”

Multiple sources told the publication that restaurateur Scott Sartiano, co-founder of the clubs 1 Oak and Zero Bond, will now take over the space. 

Representatives for Vongerichten and Sartiano didn’t immediately return The Post’s request for comment. 

The New York Times previously confirmed this May that Sartiano would be “helping to reboot” the Mercer Hotel, of which he is the creative director. In addition to the impending end of its longtime restaurant, the hotel has also recently been caught up with an ownership battle in which the majority owners sued and removed former owner André Balazs after he was accused of sexual misconduct. 

Meanwhile, in Vongerichten’s world, other recent changes have involved South Street Seaport operator the Howard Hughes Corporation buying a 25% stake in the chef’s 40-eatery empire. Down there, he’s behind something new at the Fulton Fish Market site: The Tin Building — a 55,000-square-foot destination with a dozen restaurants, a food market and three bars that will open this month.

(Vongerichten’s management team will, however, still “retain control of all day-to-day decision-making,” Hughes noted following the purchase this month, The Post previously reported.)

Vongerichten, meanwhile, is also known for running the buzzy Jean-Georges, which overlooks Central Park.