Devil May Cry 5 first launched for PlayStation 4, Xbox One, and PC via Steam on March 8, 2019, followed by Luna on December 9, 2021. The enhanced Devil May Cry 5 Special Edition launched for Xbox Series on November 10, 2020 and PlayStation 5 on November 12.

While Capcom did not directly state whether Devil May Cry 5 Special Edition numbers are included as part of the five million, total sales for Devil May Cry 5 across PlayStation 4, Xbox One, and PC were reported at 4.8 million as of December 31, 2021 and have seen regular increases of 100,000 to 200,000 units for each quarterly sales report.