ANAHEIM, Calif. — With one swing of the bat, Shohei Ohtani made the Yankees and Gerrit Cole pay for their mistakes in a 3-2 loss at Angel Stadium.

It not only led to their fourth loss in five games, the defeat also dropped the Yankees’ lead over the second-place Rays to just six games — the lowest it’s been since June 3 — as they get ready for a three-game series in St. Petersburg, Fla., starting Friday.

The Yankees seemingly had the Angels just where they wanted them heading into the bottom of the sixth.

They had just scored the game’s first runs to give Cole a two-run lead, looking for their second straight win.

But it went sideways quickly, starting with a delay to the start of the inning due to a fan running onto the field.

Josh Donaldson made a throwing error on a hard grounder by David Fletcher, sending Fletcher to second with one out in the inning.

Cole then got Mike Trout to hit a routine grounder to shortstop that Isiah Kiner-Falefa booted to bring up Ohtani with two on and one out.

The designated hitter — after appearing to argue he was hit by a pitch — took Cole deep for a three-run shot, his 30th of the season, to give the Angels a 3-2 lead.

And the Yankees lineup, which scored twice in the fifth, couldn’t get anything else going — held to just three hits — after they snapped a three-game losing streak on Tuesday.

Aaron Judge led off the ninth against Jimmy Herget with a walk. Herget then fell behind Giancarlo Stanton, 2-0.

Judge then stole second on a 2-2 pitch before Stanton walked.

Donaldson struck out, and Gleyber Torres, who doubled in a run earlier, also whiffed.

Oswaldo Cabrera, pinch-hitting for Jose Trevino, grounded out to end it.

As a result, they dropped the series to the fourth-place Angels after splitting a four-game set with the last-place A’s in Oakland.

The Yankees were mostly shut down by left-hander Patrick Sandoval, who’d allowed just three earned runs in 25 ¹/₃ innings in his previous four starts.

On Wednesday, he held the Yankees to one hit over the first four innings and allowed just three hits in seven innings.

Stanton walked to lead off the second, but Donaldson followed with a double play.

Aaron Hicks got the Yankees first hit with one out in the third, a hard grounder through the left side of the infield. He was stranded at first.

Sandoval struck out the side in order in the fourth — with Andrew Benintendi, Judge and Stanton all going down swinging, giving Sandoval six strikeouts through four innings.

Donaldson led off the fourth with a double down the left-field line and moved to third on a wild pitch with Torres at the plate.

Torres, slumping badly in the second half, came through with a double to the gap in right-center to score Donaldson and give the Yankees their first lead.

A fly ball to right sent Torres to third and Hicks drove him in with a sacrifice fly to left to make it 2-0.

Cole, who’d given up more than one run just once in his previous four starts, got some help from the Yankees’ defense early on.

Hicks made a nice catch at the track in center field on a deep fly ball by Ohtani with one on and one out in the bottom of the first.

Kiner-Falefa then made a good play on a hard grounder by Luis Rengifo to end the inning.

The Yankees also turned a pair of double plays behind Cole in the first five innings.

But that stellar defense failed them in the sixth, and the Yankees may now find themselves in a race for the division title.