A group of anti-vax protesters chanted “F–k Joe Biden” as they marched through the streets of Manhattan Monday night in the city’s annual Halloween parade.

The political statement was but a small sideshow to a frightful evening that transformed parts of the city into a scene from “The Walking Dead” — with a wide variety of zombies lumbering up Sixth Avenue.

One other zombie, in full Michael Jackson “Thriller” regalia, danced his way along the parade route.

The brash language aimed at the president was repeated by a reveler dressed as a priest who was holding a sign that read “COVID 19 is a tool of control.”

A man dressed as the “Pfizer CEO” with a zombie mask and “killing you slowly” written on his suit danced to the beat of drums and a crowd of costumed characters followed below with a “RIP COVID-19” banner.

Asked about the mandates, a “Mayuh Eric Adams” impersonator went on a rant pretending to be the real mayor of New York City.

“I am never going to drop the mandates especially for city workers,” the fake Adams said. “I’m dropping it for private workers but not for city workers because they are second-class citizens.”

His response earned boos and a “F–k Eric Adams” chant as well.

“I don’t care about anybody’s rights,” the impersonator said. “I’m the may-uh and I get stuff done.”

Politics aside, both long-time attendees and first-timers said they were glad to partake in the parade’s 49th year.

Other notable costumes included Pennywise clowns and revelers in LED masks out of horror flick “The Purge.”

On the lighter side, others dressed as the Statue of Liberty and Uncle Sam.

Upper East Sider Jade Netanya Ullmann, 48, has been attending the parade for more than thirty years. The native New Yorker went to her first New York City Halloween parade at just 16 years old and said the celebration still remains special after so many years.

She said getting the opportunity to see people “expressing themselves” is the greatest part about the parade and what keeps her coming back.

Meanwhile, Monday’s parade was the first one Isabelle Von Arx, 26, came out to after living in the city for six years.

“It’s something I wanted to do for a long time,” Von Arx, of Ridgewood, said.

“I appreciate anyone who goes all out,” she added.

Two such people dressed as a zombie bride and groom told The Post they spent five hours on their gory makeup.

Lina Castaneda, 30, and Diego Gonzalez, 40, — who are artists visiting from Columbia — said it was their first time celebrating Halloween in the US. Gonzalez wore exposed brains and white face paint while Castaneda’s look featured freaky contacts and a frighteningly sharp smile.

Another longtime attendee, Denzil Smith of Brooklyn brought along his African gray parrot named Congo to enjoy the ghoulish festivities.

Smith, a 70-year-old paralegal, said he and Congo have been coming every year since he moved to the city 35 years ago.

He said everyone loves to see Congo, who has a 26-year record of parade attendance himself.