The Blessed Madonna has released her first single in five years. “Serotonin Moonbeams” is her first solo material since 2017 single “He Is The Voice I Hear” and marks her first release on new label Warner Records. The track is an upbeat house anthem that features pop icon Uffie on groove-coaxing vocals that urge listeners to dance.

“We talked about what it was like to fall in love in the Vicks Vapo-rub, candy soaked raves of the 90s,” she explains in a statement. “It’s about ‘cuddle puddles’ and the intense emotional, physical and spiritual connections that can form when serotonal conditions are right.”

The Blessed Madonna became the voice of dance music’s post-pandemic renaissance with Fred again.. sampling her on his 2021 hit “Marea (we’ve lost dancing),” the closing track of his breakout record Actual Life (April 14 – December 17 2020). She has spent the past few months playing festivals, including a slot at Portola Fesitval.